The Role of Gut Microbiota in Health and Disease: Implications for Therapeutic Interventions

Priyanka Rajan Chaudhary

doi:10.36676/urr.v11.i3.1282

Authors

Dr. Priyanka Rajan Chaudhary Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry

DOI:

https://doi.org/10.36676/urr.v11.i3.1282

Keywords:

Gut Microbiota, Health, Disease, Therapeutic

Abstract

The gut microbiota, comprising trillions of microorganisms, profoundly influences human health and disease. This paper explores its multifaceted role, spanning from digestion and metabolism to immune regulation and brain function. Dysbiosis, or microbial imbalance, is implicated in a spectrum of disorders, including obesity, inflammatory bowel disease, and neurological conditions. Therapeutic interventions, ranging from dietary modifications to innovative microbial-based therapies, hold promise for restoring microbial equilibrium and ameliorating disease states. However, challenges remain in deciphering the complex interactions within the gut ecosystem and translating research findings into effective clinical interventions. This review underscores the critical importance of understanding the gut microbiota's dynamic interplay with the host and highlights its potential as a therapeutic target for improving human health.

References

Atomode, D (2024). ENERGY EFFICIENCY IN MECHANICAL SYSTEMS: A MACHINE LEARNING APPROACH, Journal of Emerging Technologies and Innovative Research (JETIR), 11 (5), 441-448.

Bäckhed, F., et al. (2004). The gut microbiota as an environmental factor that regulates fat storage. Proceedings of the National Academy of Sciences, 101(44), 15718-15723.

Clemente, J. C., et al. (2012). The impact of the gut microbiota on human health: an integrative view. Cell, 148(6), 1258-1270.

Cryan, J. F., & Dinan, T. G. (2012). Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nature Reviews Neuroscience, 13(10), 701-712.

Dave, A., Wiseman, M., & Safford, D. (2021). SEDAT:Security Enhanced Device Attestation with TPM2.0 (Version 1). arXiv. https://doi.org/10.48550/ARXIV.2101.06362

Dr. Neelam Raipuria Mangla. (2020). Exploring the Role of Resilience in Overcoming Traumatic Experiences. International Journal for Research Publication and Seminar, 11(4), 227–233. Retrieved from https://jrps.shodhsagar.com/index.php/j/article/view/1221

Dr. Rajender Kumar Pandey. (2017). Study on burn injury, assessment of allegations of self-inflection Medico Legal Cases brought to tertiary Hospital, Aurangabad. International Journal for Research Publication and Seminar, 8(7), 41–48. Retrieved from https://jrps.shodhsagar.com/index.php/j/article/view/1158

Dr Rinki. (2017). An Examination of Health Psychology. Innovative Research Thoughts, 3(6), 124–127. Retrieved from https://irt.shodhsagar.com/index.php/j/article/view/149

Goyal, A. (2024). Advancements in Gene Therapy for Rare Genetic Disorders. Shodh Sagar Journal for Medical Research Advancement, 1(1), 10–18. https://doi.org/10.36676/ssjmra.v1.i1.02

Kamada, N., et al. (2013). Regulated virulence controls the ability of a pathogen to compete with the gut microbiota. Science, 336(6086), 1325-1329.

Kumar, V. (2017). Study of DNA sequencing, and sequencing methods. Universal Research Reports, 4(7), 122–125. Retrieved from https://urr.shodhsagar.com/index.php/j/article/view/228

Lynch, S. V., & Pedersen, O. (2016). The human intestinal microbiome in health and disease. New England Journal of Medicine, 375(24), 2369-2379.

Turnbaugh, P. J., et al. (2007). The human microbiome project. Nature, 449(7164), 804-810.

Qin, J., et al. (2010). A human gut microbial gene catalogue established by metagenomic sequencing. Nature, 464(7285), 59-65.

Rooks, M. G., & Garrett, W. S. (2016). Gut microbiota, metabolites and host immunity. Nature Reviews Immunology, 16(6), 341-352.

Ritcha Saxena, Ishrat Nur Ridi, & Kevin Carnewale. (2023). Towards Inclusive Excellence: Advancing Diversity and Equity in Medical Education. International Journal for Research Publication and Seminar, 14(4), 192–203. Retrieved from https://jrps.shodhsagar.com/index.php/j/article/view/441

Ritcha Saxena, Kevin Carnevale, Oleg Yakymovych, Michael Salzle, Kapil Sharma, & Ritwik Raj Saxena. (2023). Precision, Personalization, and Progress: Traditional and Adaptive Assessment in Undergraduate Medical Education. Innovative Research Thoughts, 9(4), 216–223. Retrieved from https://irt.shodhsagar.com/index.php/j/article/view/704

Satyanarayan Kanungo, 2021. "Enhancing IoT Security and Efficiency: The Role of Cloud Computing and Machine Learning" ESP Journal of Engineering & Technology Advancements 1(1): 7-14. DOI: https://doi.org/10.56472/25832646/JETA-V1I1P099

Satpute, P. V., & Sigru, R. (2018). Review of Organic and Chemical Synthesis. Innovative Research Thoughts, 4(4), 173–176. Retrieved from https://irt.shodhsagar.com/index.php/j/article/view/815

Sender, R., Fuchs, S., & Milo, R. (2016). Revised estimates for the number of human and bacteria cells in the body. PLOS Biology, 14(8), e1002533.

Sonnenburg, J. L., & Fischbach, M. A. (2011). Community health care: therapeutic opportunities in the human microbiome. Science Translational Medicine, 3(78), 78ps12.

Vamsi Katragadda "Ethical AI in Customer Interactions: Implementing Safeguards and Governance Frameworks" Iconic Research And Engineering Journals Volume 7 Issue 12 2024 Page 394-397