The Microbiome-Brain Axis: Exploring the Gut-Brain Connection in Neurological Disorders

Kartik Mehta

doi:10.36676/urr.v11.i3.1283

Authors

Dr. Kartik Mehta Maulana Azad Medical College (MAMC), New Delhi

DOI:

https://doi.org/10.36676/urr.v11.i3.1283

Keywords:

Nervous system, central nervous system, gastrointestinal diseases

Abstract

The association and interaction between the central nervous system (CNS) and enteric nervous system (ENS) is well established. Essentially ENS is the second brain, as we call it. We tried to understand the structure and function, to throw light on the functional aspect of neurons, and address various disease manifestations. We summarized how various neurological disorders influence the gut via the enteric nervous system and/or bring anatomical or physiological changes in the enteric nervous system or the gut and vice versa. It is known that stress has an effect on Gastrointestinal (GI) motility and causes mucosal erosions. In our literature review, we found that stress can also affect sensory perception in the central nervous system. Interestingly, we found that mutations in the neurohormone, serotonin (5-HT), would result in dysfunctional organ development and further affect mood and behavior. We focused on the developmental aspects of neurons and cognition and their relation to nutritional absorption via the gastrointestinal tract, the development of neurodegenerative disorders in relation to the alteration in gut microbiota, and contrariwise associations between CNS disorders and ENS.

References

Ahmed, I. (2018). Study of Objectives and functions of NHM in Haryana and major schemes/activities for implementing the Maternal Health Program in context of Haryana. Universal Research Reports, 5(2), 71–74. Retrieved from https://urr.shodhsagar.com/index.php/j/article/view/594

Arora, K. (2017). Blood Brain Barrier and Hepatic Encephalopathy. Innovative Research Thoughts, 3(11), 394–407. Retrieved from https://irt.shodhsagar.com/index.php/j/article/view/388

Baetge, G.; Gershon, M.D. Transient catecholaminergic (TC) cells in the vagus nerves and bowel of fetal mice: Relationship to the development of enteric neurons. Dev. Biol. 1989, 132, 189–211.

Carabotti, M.; Scirocco, A.; Maselli, M.A.; Severi, C. The gut-brain axis: Interactions between enteric microbiota, central and enteric nervous systems. Ann. Gastroenterol. 2015, 28, 203–209.

Gastroenterol. Hepatol. 2009, 6, 306–314. 2. Cryan, J.F.; O’Riordan, K.J.; Sandhu, K.; Peterson, V.; Dinan, T.G. The gut microbiome in neurological disorders. Lancet Neurol. 2020, 19, 179–194.

Gianino, S.; Grider, J.R.; Cresswell, J.; Enomoto, H.; Heuckeroth, R.O. GDNF availability determines enteric neuron number by controlling precursor proliferation. Development 2003, 130, 2187–2198.

Macia, L.; Tan, J.; Vieira, A. Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome. Nat. Commun. 2015, 6, 6734.

Ms Shelly. (2017). Who Benefit From Essential Drug Price Control, Need of Price Control In India -A review. Innovative Research Thoughts, 3(9), 155–163. Retrieved from https://irt.shodhsagar.com/index.php/j/article/view/247

Nezami, B.G.; Srinivasan, S. Enteric Nervous System in the Small Intestine: Pathophysiology and Clinical Implications. Curr. Gastroenterol. Rep. 2010, 12, 358–365.

Patel, A. D. N. B. C. (2023). RARES: Runtime Attack Resilient Embedded System Design Using Verified Proof-of-Execution (Version 1). arXiv. https://doi.org/10.48550/ARXIV.2305.03266

Priya. (2017). The Impact of Yoga on Stress Reduction and Mental Well-Being. Innovative Research Thoughts, 3(3), 1–9. Retrieved from https://irt.shodhsagar.com/index.php/j/article/view/93

Prit Pal, & Dr. Atul Shukla. (2022). Yoga’s effects on athletes’ balance and coordination. Innovative Research Thoughts, 8(4), 293–297. Retrieved from https://irt.shodhsagar.com/index.php/j/article/view/1208

PRABHU NAUTIYAL. (2020). DARUHARIDRA: A PHARMACOGNOSTICAL STUDY. International Journal for Research Publication and Seminar, 11(4), 92–95. Retrieved from https://jrps.shodhsagar.com/index.php/j/article/view/1202

Rao, M.; Gershon, M.D. The bowel and beyond: The enteric nervous system in neurological disorders. Nat. Rev. Gastroenterol. Hepatol. 2016, 13, 517–528.

Rhee, S.H.; Pothoulakis, C.; Mayer, E.A. Principles and clinical implications of the brain–gut–enteric microbiota axis. Nat. Rev.

Satyanarayan Kanungo, Amrendra Kumar & Rajendra Zagade (2022). OPTIMIZING ENERGY CONSUMPTION FOR IOT IN DISTRIBUTED COMPUTING. International Journal of Emerging Technologies and Innovative Research, 9(6), k514-k522

SHARMA, D. A. (2017). Homoeopathic Approach To Malignancy. Innovative Research Thoughts, 3(2), 34–39. Retrieved from https://irt.shodhsagar.com/index.php/j/article/view/75

Singla, A. (2024). Precision Medicine: Tailoring Treatment to Individual Genetic Profiles. Shodh Sagar Journal for Medical Research Advancement, 1(1), 27–37. https://doi.org/10.36676/ssjmra.v1.i1.04

Simi Nath. (2023). The Theory of Language Acquisition. International Journal for Research Publication and Seminar, 14(1), 225–229. Retrieved from https://jrps.shodhsagar.com/index.php/j/article/view/363

Strandwitz, P. Neurotransmitter modulation by the gut microbiota. Brain Res. 2018, 1693, 128–133.

Stoddard, C.J. Current concepts of gastrointestinal motility and electrical activity. Br. J. Hosp. Med. 1978, 20, 426+428–434.

Sumit, & Amit Mahal. (2017). Survey of various techniques used for brain computer interface. International Journal for Research Publication and Seminar, 8(6). Retrieved from https://jrps.shodhsagar.com/index.php/j/article/view/1145