Study of serum zinc alkaline phosphatase and ascorbic acid level in diabetes mellitus

Abstract

Diabetes mellitus (DM) comprises a group of metabolic disorders presenting with hyperglycemia resulting from insulin deficiency or 1decrease glucose utilization and increased glucose production. Type- I diabetes is the consequence of an autoimmune – mediated destruction of pancreatic β-cell, leading to insulin deficiency. Type- II diabetes is characterized by insulin resistance and relative, rather than absolute, insulin deficiency. Diabetes mellitus is primarily a metabolic disorder arising from a lack of or resistance to insulin, which results in the impairment of uptake and storage of glucose and its reduced glucose utilization for energy purposes leading to the condition called hyperglycemia. Prolonged exposure to elevated glucose induces repeated acute changes in intracellular metabolism and cumulative long-term changes in the structure and function of biological macromolecules. A few published reports of both in vitro and in vivo studies on the interactions among Zinc (Zn), Alkaline- phosphatase (AP) enzyme activity, Ascorbic acid (AA) and glucose drew attention to their alterations in diabetic states. These were reviewed and since relatively few reports existed with special reference to diabetes it was proposed to carry out a preliminary study of their levels in the blood of the diabetic as well as healthy subjects for their likely correlations and implications. The present work was aimed at evaluating the serum Zinc, Alkaline phosphatase and Ascorbic acid levels in Diabetes Mellitus and to compare their levels in normal and individuals