Solubility enhancement strategies for poorly water- soluble drugs in solid dispersions: A review
Keywords:
Water soluble drug, Spray drying technologyAbstract
Solid dispersions have been employed to enhance the dissolution rates of poorly water- soluble drugs. Many approaches have been investigated for the preparation of solid dispersions. This paper reports various solubility enhancement strategies in solid dispersion. The approaches described are fusion (melting), solvent evaporation, lyophilization (freeze drying), melt agglomeration process, extruding method, spray drying technology, use of surfactant, electro static spinning method and super critical fluid technology. The paper also highlights the potential applications and limitations of these approaches in solid dispersions.
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