PREPARATION AND EVALUATING PRONIOSOMAL GEL OF ISOCONAZOLE

Authors

  • Sharma P Assistant Professor, SOS In Pharmaceutical Sciences, JIWAJI University, Gwalior
  • Sharma M Associate Professor, SOS In Pharmaceutical Sciences, JIWAJI University, Gwalior

Keywords:

proniosomal gel, isoconazole

Abstract

A fungus is a germ that ranges from something tiny and barely visible all the way to something big like a mushroom. They are all around us and don't usually cause any problems. Occasionally fungi (which is the plural of fungus) can cause more serious infections, particularly if the host is already ill. This can happen if the host is taking medicines that lower the immune system, like chemotherapy. A fungus is just a type of germ. They can range from tiny, barely visible specks that float around in the air, all the way up to large growths like mushrooms. Fungi (the plural of fungus) are all around us and don't usually cause any problems. An existence of transdermal delivery tool, proniosomal gel, has established to showed remarkable development for lipophilic/hydrophilic drugs over additional formulations. This research work has aimed to develop and evaluate proniosomal gel of isoconazole. The research aimed to evaluate the drug on the basis of its Physiochemical properties of isoconazole, Melting point, Solubility studies, Calibration curve using UV spectrometry, and Drug excipient compatibility study. The drug was studied at 40ºC ± 75% RH for 1 month and was also studied at room temperature for same time period.

References

B. D. Thimmaraju R, A. Nasir Kurnool, T. D. R α, and A. Nasir Kurnool σ, “Proniosomal Gel: Formulation and Charecterization of an Antifungal Drug (Butenafine Hcl) Loaded Proniosomes for Topical Delivery,” Toxicol. Med., vol. 20, no. 5, 2020.

G. Benipal, “Design, development and evaluation of proniosomal gel of an antifungal drug - Ketoconazole,” Int. J. Pharm. Sci. Rev. Res., vol. 31, no. 2, pp. 265–277, 2015.

P. M. Kasar, K. Kale, and D. G. Phadtare, “Formulation and Evaluation of Topical Antifungal Gel Containing Itraconazole,” Int. J. Curr. Pharm. Res., vol. 10, no. 4, p. 71, 2018, doi: 10.22159/ijcpr.2018v10i4.28470.

N. Oza and S. Sagar, “a Statistical Approach To Development of Sustained Release Proniosomal,” Int. J. Pharm. Sci. Res., vol. 11, no. 11, pp. 5508–5517, 2020, doi: 10.13040/IJPSR.0975-8232.11(11).5508-17.

A. Garg, G. S. Sharma, A. K. Goyal, G. Ghosh, S. C. Si, and G. Rath, “Recent advances in topical carriers of anti-fungal agents,” Heliyon, vol. 6, no. 8, p. e04663, 2020, doi: 10.1016/j.heliyon.2020.e04663.

N. Kaur, A. Bains, R. Kaushik, S. B. Dhull, F. Melinda, and P. Chawla, “A review on antifungal efficiency of plant extracts entrenched polysaccharide‐based nanohydrogels,” Nutrients, vol. 13, no. 6, pp. 1–26, 2021, doi: 10.3390/nu13062055.

P. K. Bolla et al., “Clotrimazole loaded ufosomes for topical delivery: Formulation development and in-vitro studies,” Molecules, vol. 24, no. 17, 2019, doi: 10.3390/molecules24173139.

Downloads

Published

2022-09-30

How to Cite

Sharma, P., & Sharma, M. (2022). PREPARATION AND EVALUATING PRONIOSOMAL GEL OF ISOCONAZOLE. Universal Research Reports, 9(3), 13–22. Retrieved from https://urr.shodhsagar.com/index.php/j/article/view/988

Issue

Section

Original Research Article